Section C Project C01
Regulation of autoantibody-induced bone inflammation and osteoclastogenesis via the C-type lectin receptor Mincle
Project leaders
Signaling via Fcg-receptors (FcγR) and the common FcRγ-chain is important for inflammation-induced osteoclastogenesis in arthritis. Of note, other cell surface receptors such as C-type lectins family transduce activating signals via the FcRγ-chain (Seeling, et al., 2013, Seeling, et al., 2023). Thus, depending on ligand availability, independent sets of receptors may compete for the common FcRγ-chain to trigger downstream activation of tyrosine-protein kinase SYK and phosphoinositide (PI)3 kinase to generate osteoclasts. Therefore, the project will investigate the crosstalk between canonical FcγRs and the C-type lectin receptor Mincle in the context of inflammatory bone loss. The long-term goal of the project is to create an interaction map of FcRγ-chain dependent cell surface receptors expressed during inflammatory osteoclastogenesis allowing identifying positive and negative checkpoints involved in inflammatory bone remodelling.
