Category: Newsroom

What is your current position?

I am a doctoral researcher in the scientific laboratory of the Department of Orthodontics and Orofacial Orthopedics at Universitätsklinikum Erlangen where we investigate molecular and developmental mechanisms that contribute to orofacial diseases and shape craniofacial biology. I am part of the Transregio CRC 369 “DIONE – Degeneration of Bone due to Inflammation”.

What is your main research focus?

Within DIONE, my research explores how inflammatory processes — whether sterile or non-sterile — impact bone health. My research investigates how osteoclasts are shaped by a complex cellular microenvironment. Using advanced tissue-level bioimaging and niche-specific transcriptional profiling, our goal is to understand how these microenvironmental cues drive inflammation-induced bone loss in models of arthritis and periodontitis.

What does your typical workday look like?

My everyday work combines planning and conducting laboratory experiments with extensive data analysis. Outside the bench, I focus on interpreting results, preparing figures, and engaging in scientific discussions with colleagues.

What is your current position?

I work as a PhD student at a collaboration project between the Medicine 3 of  Uniklinikum Erlangen (Uderhardt lab) and the Max-Planck-Zentrum für Medizin und Physik (Zaburdaev lab). This collaboration allows me to work closely with colleagues from diverse backgrounds, ranging from medicine and biology to computer science and theoretical physics.

What is your main research focus?

Our research aims to uncover how cells communicate within intercellular networks. We are particularly interested in networks of osteocytes or interstitial fibroblast, which form intricate connections that allow cells to coordinate their functions and even share resources. A key focus of our work is on calcium signaling — a fundamental process through which cells exchange information. By combining experimental observations with mathematical modeling, we study how calcium signals propagate through these networks and how changes in network organization, such as those occurring in disease, can disrupt communication. Ultimately, this approach helps us better understand how cellular miscommunication contributes to tissue dysfunction and pathology.

What does your typical workday look like?

As a member of two distinct research groups, I need to organize my work accordingly. Typically, my schedule includes meetings and talks. Before and after these appointments, I am free to engage in self-organized work, such as reading the literature, adjusting code, creating plots and figures, and writing.

What is your current position?

I am a Research Group Leader for Osteo- and Dentalimmunology. Within DIONE, I collaborate with Dr. Ulrike Baschant on project A05: “Investigating the role of iron in inflammation-induced bone loss: insights into osteoclast metabolism.”

What is your main research focus?

My group investigates the intracellular metabolism of immune and bone cells, with a strong emphasis on how metabolic reprogramming and altered bioenergetics drive inflammation and bone destruction. We are particularly interested in the crosstalk between bone and immune cells, aiming to unravel how their interactions shape the course of inflammatory and degenerative diseases.

Another key aspect of our work is the oral microbiome and its contribution to the pathogenesis of autoimmune diseases. By understanding these mechanisms, we hope to identify novel strategies for both prevention and therapy.

What does your typical workday look like?

My key task is to create an environment where my team can work efficiently by taking care of challenges behind the scenes. I spend my days mentoring PhD students, keeping projects on track, collaborating with clinical partners, and dedicating time to developing grant proposals and publications. What makes an ordinary day truly exciting are new collaborations, setting up novel experiments and models, and celebrating shared successes with the team.

What is your current position?

I am Professor of Molecular Bone Biology and scientific director of the Bone Lab at the Medical Faculty of the Technical University of Dresden. I also serve as the co-speaker of the Transregio CRC 369 “DIONE – Degeneration of Bone due to Inflammation” and as the speaker of the research unit FOR 5146 “FerrOs – Osteohepatic axis and bone”.

What is your main research focus?

We focus on understanding the cellular and molecular mechanisms of bone diseases related to inflammation, hormonal dysregulation, hematological disorders and malignancy. We focus on signaling pathways including BMP and Wnt signaling, FGF-23 as well as dysregulations in cellular metabolism.

What does your typical workday look like?

On most days, lots of emails for organizing and coordinating activities that are related to science, administrative and organizational aspects, or work for scientific societies and committees of our faculty. The most fun part though is talking to the scientists about their work, writing/correcting manuscripts, and writing grant proposals.

What is your current position?

I am research group leader the Department of Medicine 3 – Rheumatology & Immunology at Friedrich‑Alexander‑University and Uniklinikum Erlangen. I also serve as steering committee member of the Transregio CRC 369 “DIONE – Degeneration of Bone due to Inflammation”.

What is your main research focus?

My research team investigates the mechanisms underlying the development of autoimmunity and the interplay of autoantibodies, innate immune cells, and bone loss in rheumatologic diseases.

We focus on:

• Plasma cell development, antibody characteristics and the impact of glycosylation in (auto)immunity
• Regulation of osteoclast activity and bone homeostasis

What does your typical workday look like?

A typical day starts with a well structured to-do list that becomes totally crashed within the first hour. The rest of the day is a mixture of problem solving, experimental design, many discussions with my research team and collaborators, writing and occasional celebrations of breakthroughs.

What is your current position?

I am a group leader focused on tissue regeneration and the resolution of inflammation at the Center for Regenerative Therapies Dresden (CRTD), part of Technische Universität Dresden (TUD). I am actively involved in teaching within the Master’s program Regenerative Biology and Medicine.

Within the Transregio CRC 369 “DIONE – Degeneration of Bone due to Inflammation,” I lead project B03, which investigates the protective role of eosinophils in bone loss associated with inflammatory arthritis.

What is your main research focus?

My research focuses on the often overlooked homeostatic and regulatory roles of eosinophils, exploring how these cells, traditionally viewed as pro-inflammatory effectors, also contribute to the resolution of inflammation and tissue regeneration across multiple organs. Building on our discoveries of regulatory eosinophil populations in joints and bone marrow, we investigate how tissue microenvironments shape eosinophil phenotypes at metabolic, epigenetic, and proteomic levels. Our long-term goal is to reprogram eosinophils toward a tissue-protective, pro-resolving state to improve outcomes in chronic inflammatory diseases.

What does your typical workday look like?

I recently launched my own research group in Dresden and the first months have been all about building a lab from the ground up and getting our science rolling. These days, my routine is a mix of mentoring amazing PhD, master’s, and bachelor’s students, staying hands-on at the bench, analyzing data, leading lab meetings, collaborating with clinical partners, and advancing grants and publications. I also teach in the Master’s program Regenerative Biology and Medicine, where I get to share why immunology is such a powerful field and how it shapes our fight against chronic inflammatory diseases.

What is your current position?

I am a postdoctoral researcher at the Bone Lab Dresden. Within DIONE, I am responsible for the experimental work of project A03 in Dresden, led by Prof. Sebastian Zundler (FAU Erlangen) and Dr. Juliane Salbach-Hirsch (Bone Lab Dresden). Beyond DIONE, I also serve as a principal investigator on  osteohematology-related research projects.

What is your main research focus?

My work centers on uncovering how anemia shapes bone health, specifically, how changes in bone-forming osteoblasts under anemic conditions can contribute to osteoporosis. I am interested in the journey of erythrocytes from hematopoietic stem cells in myelodysplastic neoplasms, and how immune cells as macrophages and T cells influence this process. Broadly, my research weaves together themes of anemia and chronic inflammatory conditions (including IBD), all with the goal of better understanding the crosstalk between blood, bone, and the immune system.

What does your typical workday look like?

Not two days are exactly alike, but my work usually balances mentoring, collaboration, and performing experiments. I spend part of my day guiding my PhD student and other trainees, coordinating ongoing projects, and diving into data from in vitro and in vivo models. Aside the lab work, I spend time on preparing applications for study approvals, contributing to grant proposals and publications, and teaching medical students. It is a mix of science, strategy, and teamwork.

We are pleased to look back on this year’s TRR369 DIONE International Retreat, held in the beautiful setting of Kloster Holzen. During the two intensive and inspiring days, the members of the DIONE consortium exchanged up-to-date information on their ongoing research projects and used the networking opportunities to establish new scientific collaborations.

A particular highlight were the talks of the guests Prof. Geert Carmeliet (Leuven) and Prof. Claudine Blin (Nice), who generously offered fascinating insights into their research and gave us valuable assessments of the scientific status of the consortium. We thank you for your participation and impressive contributions!

DIONE is an interdisciplinary research network at the Erlangen, Dresden, Ulm and Dortmund sites, which is headed by Prof Aline Bozec and Prof Martina Rauner and has been funded by the Deutsche Forschungsgemeinschaft (DFG) – German Research Foundation since 2024.

The research objective of the Collaborative Research Centre/Transregio 369 ‘DIONE’ (DegeneratIon of bONE induced by inflammation) is to understand and specifically influence the complex interactions between the immune system and bone tissue in inflammation-induced bone loss. The long-term goal of DIONE is to develop new therapeutic approaches for the treatment of inflammation-related bone diseases and to pave the way for innovative therapies.

As part of the DIONE Consortium, the Andreev Lab offered exciting insights into research on inflammatory bone loss at the 22nd Long Night of Science in Dresden.
Children explored the interaction between osteoblasts and osteoclasts in a playful way – including observing real cells under the microscope.
There were quizzes, hands-on stations, and answers to questions like: Why do astronauts lose bone mass in space? How does nutrition protect our skeleton?
Adults engaged with scientific posters, fascinating conversations, and showed great interest.
We thank all visitors for a wonderful evening full of curiosity and exchange!

Technische Universität Dresden, AG Darja Andreev, Pauline Porschitz

Katja Dreißigacker has joined the clinical and scientific management team at the Department of Medicin 3 – Rheumatology and Immunology as project coordinator for SFB/TRR369 DIONE.

She has been involved in inflammation research in Erlangen since 2012. For many years, she worked in the laboratory, conducting experiments, organising day-to-day research activities and ensuring that everything ran smoothly. She later moved into laboratory management, where she further developed her organisational skills and strengthened teams in their work.

Since 2023, she has been coordinating the NOTICE clinician scientist programme – and now also CRC/Transregio DIONE, which connects the sites Erlangen, Dresden, Ulm and Dortmund.

Katja combines scientific understanding with a keen eye for organisation, teamwork and sustainable structures. She thus builds the perfect bridge between research and management and enriches our team with her energy, determination and experience.

Welcome, dear Katja –  we are delighted to have you on our team.

We are proud to share that two DIONE doctoral researchers received top honors at the 2nd Conference on Experimental Endocrinology in Freising!

Heidi Lunze (TU Dresden, B06 project of PD Dr. rer. nat. Ulrike Baschant) was awarded the Best Presentation Award for her talk:
“Specific overexpression of 11β-HSD1 as a model of local glucocorticoid action”

Ann-Kathrin Eiers (University of Ulm, B06 project of Prof. Dr. Jan Tuckermann) received the Best Poster Award for her poster:
“Fibroblast-like synoviocytes (FLS) are essential for resolution of inflammation in arthritis”

We are truly delighted by this recognition and proudly congratulate both researchers on this great success!

The DIONE project B06 “Genetically-driven cell-specific activation of glucocorticoids and GR as a therapeutic tool in inflammatory arthritis” investigates how glucocorticoids act specifically on certain cell types in order to make better therapeutic use of their powerful anti-inflammatory effects while minimizing side effects such as osteoporosis.
By studying cell-specific glucocorticoid signaling in immune and stromal cells, the project aims to develop precise and safer therapeutic strategies for inflammatory arthritis.